Monday, September 21, 2020

Targeted Therapy for SLL

Targeted therapy
These drugs attack one or more specific targets on cancer cells. Your doctor might suggest them if you've already had another treatment that didn't work. Two examples are ibrutinib (Imbruvica) and idelalisib (Zydelig). Both are pills.

Scientists also are looking for new ways to treat SLL in clinical trials. These test new drugs to see if they are safe and if they work. They often are a way for people to try new medicine that isn't available to everyone. Your doctor can tell you if one of these trials might be a good fit for you.

Besides new drugs, another treatment that may be part of a clinical trial is a stem cell transplant.

Stem cells are in the news a lot, but usually when you hear about them they're referring to "embryo" stem cells that are used in cloning. The stem cells in a transplant are different. They live in your bone marrow and help make new blood cells.

This procedure may use your own stem cells or stem cells from a donor.

If a donor supplies them, you'll need to find one who is the right match for you, so your body doesn't reject the new stem cells, or start fighting them the way it would fight an infection.

Close relatives, such as your brother or sister, are the best chance for a good match. If that doesn't work out, you need to get on a list of potential donors from strangers. Sometimes the best chance for the right stem cells for you will be from someone who's the same race or ethnicity as you.

Before the transplant, you'll most likely need to get treated with high doses of chemo for about a week or two. Sometimes radiation therapy is also used.

This can be a tough process, because you may get side effects like nausea and mouth sores. Certain medications can make these side effects less severe.

When the high-dose chemo is done, you'll start the transplant. You get the new stem cells through an IV. You won't feel any pain from this, and you're awake while it’s happening.

After your transplant, it could take 2 to 6 weeks for the stem cells to multiply and start making new blood cells. During this time you may be in the hospital, or at the very least, will need to make visits every day to get checked by your transplant team. It can take 6 months to a year until the number of normal blood cells in your body gets back to what it should be.


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